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Ренат Рашитович Ахмеров

Доктор медицинских наук
разработчик системы Плазмолифтинг®

Effect of single injection of Platelet-Rich Plasma in comparison with corticosteroid on knee osteoarthritis: a double-blind randomized clinical trial

Forogh B1, Mianehsaz E, Shoaee S, Ahadi T, Raissi GR, Sajadi S.

Abstract

AIM:

Evidence on the effect of Platelet-Rich Plasma (PRP) in treating osteoarthritis (OA) is insufficient. Therefore, the present study compares the effects of a one-time injection of PRP and corticosteroid (CS) as two types of treatment for the patients suffering from osteoarthritis.

METHODS:

In the present randomized double blind clinical trial, the participants who suffered from knee osteoarthritis (Grades II/III), were randomly divided into two groups: intra articular injection of PRP and CS. Knee injury and osteoarthritis outcome score (KOOS), the 20-meter-walk test, active and passive ranges of motions (ROM), flexion contracture, and pain intensity based on Visual Analog Scale (VAS) were assessed before, 2-months, and 6-months after interventions.

RESULTS:

41 participants (48 knees) were involved in the research (66.7% women; average age of 61.1±7.0 years old). Compared to the group treated with corticosteroid, pain relief (df:6 ,35 ;F=11.0 ;p=0.007), symptom free (df:6 ,35 ;F=23.0 ;p<0.001), activities of daily living (ADL) (df:6 ,35 ;F=10.7 ;p=0.005) and quality of life (df:6 ,35 ;F=5.2 ;p=0.02) in the RPR group were significantly higher, but sporting ability was not different between the 2 groups (df:6 ,35 ;F=0.6 ;p=0.55). PRP prescription was significantly more helpful for relieving patients' pain (VAS) compared to corticosteroids (df:6,35;F=32.0 ;p,0.001).It's also notable that using PRP was more helpful in improving the 20-meter-walk test than corticosteroid treatment (df:6 ,35 ;F=7.4 ;p=0.04) but none of the treatments had any impact on active flexion ROM ?passive flexion ROM and flexion contracture (p>0.05).

CONCLUSION:

Our study demonstrated that one shot of PRP injection, decreased joint pain more and longer-term, alleviated the symptoms, and enhanced the activity of daily living and quality of life in short-term duration in comparison with CS.

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